GP Nolva/Nolvadex GP Nolva/Nolvadex GP Nolva/Nolvadex

GP Nolva/Nolvadex (Tamoxifen Citrate) tablets, a nonsteroidal antiestrogen, are for oral administration. Chemically, tamoxifen is the trans-isomer of a triphenylethylene derivative.
GP Nolva/Nolvadex (Tamoxifen Citrate) is a medicine that blocks the effects of in the body. It is usually used to treat breast cancer in women or men, but may also be used to treat other kinds of cancer. GP Nolva/Nolvadex (Tamoxifen Citrate) may also be used to reduce the risk of developing breast cancer in women who have a high risk. Women at high risk for developing breast cancer are at least 35 years old and have a combination of risk factors that make their chance of developing breast cancer 1.67% or more over the next 5 years. Your doctor will help to determine your risk of developing breast cancer.
Be sure to tell your doctor of any allergies you have whether it is to medication or food, preservatives, or dyes. Tell your doctor immediately if you are, or become pregnant, or are breastfeeding, as it is unknown how GP Nolva/Nolvadex (Tamoxifen Citrate) may affect your baby. Also, tell your doctor of any other medications you are taking, including vitamins and supplements, and any medical conditions you may have.
It is very important that you take this medicine exactly as your doctor tells you to. If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose.

Metabolism:
Tamoxifen is extensively metabolized after oral administration. N-desmethyl tamoxifen is the major metabolite found in patients' plasma. The biological activity of N-desmethyl tamoxifen appears to be similar to that of tamoxifen. 4-Hydroxytamoxifen and a side chain primary alcohol derivative of tamoxifen have been identified as minor metabolites in plasma. Tamoxifen is a substrate of cytochrome P-450 3A, 2C9 and 2D6, and an inhibitor of P-glycoprotein.

Excretion:
Studies in women receiving 20 mg of 14C tamoxifen have shown that approximately 65% of the administered dose was excreted from the body over a period of 2 weeks with fecal excretion as the primary route of elimination. The drug is excreted mainly as polar conjugates, with unchanged drug and unconjugated metabolites accounting for less than 30% of the total fecal radioactivity.

SIDE EFFECTS
Tell your doctor as soon as possible if any of the following side effects occur: (for both females and males) anxiety, blistering, peeling, or loosening of skin and mucous membranes, blurred vision, chest pain, confusion, cough, dizziness, fainting, fast heartbeat, lightheadedness, pain or swelling in legs, shortness of breath or trouble breathing, weakness or sleepiness, or yellow eyes or skin.
(For females only) change in vaginal discharge; chills, fever, hoarseness, lower back or side pain, pain or feeling of pressure in pelvis, pain, redness, or swelling in your arm or leg, painful or difficult urination, rapid shallow breathing, skin rash or itching over the entire body, sweating, vaginal bleeding, or wheezing.
GP Nolva/Nolvadex (Tamoxifen Citrate) Tablets, a nonsteroidal antiestrogen, are for oral administration. GP Nolva/Nolvadex (Tamoxifen Citrate) Tablets are available as:
20 mg Tablets: Each tablet contains 30 mg of tamoxifen citrate which is equivalent to 20 mg of tamoxifen.
Chemically, GP Nolva/Nolvadex (Tamoxifen Citrate) is the trans-isomer of a triphenylethylene derivative.