Prograf (tacrolimus) is a drug that suppresses the immune system and is used to prevent rejection of transplanted organs. Prograf (tacrolimus) accomplishes its immune-suppressing effecting by inhibiting an enzyme (calcineurin) crucial for the multiplication of T-cells, cells that are vital to the immune process. The use of oral Prograf (tacrolimus) allows transplantation specialists to reduce the dose of steroids which are also used to prevent rejection. This "steroid-sparing effect" is important because of the many side effects that can occur when larger doses of steroids are used for a long period of time.

USAGE:

    -  Apply a thin layer of Prograf (tacrolimus) to the affected skin twice daily. The minimum amount should be rubbed in gently and completely to control signs and symptoms of atopic dermatitis. Stop using when signs and symptoms of atopic dermatitis resolve.
    - If signs and symptoms (itch, rash, and redness) do not improve within 6 weeks, patients should be re-examined by their healthcare provider to confirm the diagnosis of atopic dermatitis.
    - Continuous long-term use of topical calcineurin inhibitors, including Prograf should be avoided, and application should be limited to areas of involvement with atopic dermatitis. The safety of Prograf under occlusion, which may promote systemic exposure, has not been evaluated. Prograf should not be used with occlusive dressings.
Prograf (tacrolimus) is taken twice daily. Doses vary widely and are based on blood tests that measure the amount of tacrolimus in the body. Taking tacrolimus with food can reduce some of the abdominal pain that can occur with this medicine; however, food can reduce the amount of tacrolimus that is absorbed. This is especially true with fatty foods. Thus, tacrolimus is best taken without food. If it must be taken with food, it should be taken with non-fatty food.

SIDE EFFECTS:

Similar to other dermatological products currently marketed, it is advised that individuals practice safe sun techniques to avoid direct exposure to natural or artificial sunlight. Skin burning and itching have been associated with the application of Prograf (tacrolimus) however, the incidence of these events decreased as the disease improved.
Do not consume grapefruit or grapefruit juice during treatment with tacrolimus unless your doctor has told you do. Prograf (tacrolimus) can have a dangerous interaction with grapefruit or grapefruit juice.
Prograf (tacrolimus) can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.