T4 Ibrahim (Levothyroxine) is a replacement for a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism. T4 Ibrahim (Levothyroxine) is given when the thyroid does not produce enough of this hormone on its own.
T4 Ibrahim (Levothyroxine) treats hypothyroidism (low thyroid hormone). T4 Ibrahim (Levothyroxine) is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer.

Levothyroxine sodium is used for the following indications:

Hypothyroidism - As replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. Specific indications include: primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism and subclinical hypothyroidism. Primary hypothyroidism may result from functional deficiency, primary atrophy, partial or total congenital absence of the thyroid gland, or from the effects of surgery, radiation, or drugs, with or without the presence of goiter.

Pituitary TSH Suppression - In the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis, multinodular goiter and, as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

SIDE EFFECTS:

Cardiovascular: Angina, arrhythmia, blood pressure increased, cardiac arrest, flushing, heart failure, MI, palpitation, pulse increased, tachycardia.
Central nervous system: Anxiety, emotional lability, fatigue, fever, headache, hyperactivity, insomnia, irritability, nervousness, pseudotumor cerebri (children), seizure (rare).
Dermatologic: Alopecia
Endocrine & metabolic: Fertility impaired, menstrual irregularities
Gastrointestinal: Abdominal cramps, appetite increased, diarrhea, vomiting, weight loss
Hepatic: Liver function tests increased
Neuromuscular & skeletal: Bone mineral density decreased, muscle weakness, tremor, slipped capital femoral epiphysis (children)
Respiratory: Dyspnea
Miscellaneous: Diaphoresis, heat intolerance, hypersensitivity (to inactive ingredients, symptoms include urticaria, pruritus, rash, flushing, angioedema, GI symptoms, fever, arthralgia, serum sickness, wheezing)

OVERDOSAGE:

Chronic: Chronic overdose may cause hyperthyroidism, weight loss, nervousness, sweating, tachycardia, insomnia, heat intolerance, menstrual irregularities, palpitations, psychosis, and fever. Overtreatment of children may result in premature closure of epiphyses or craniosynostosis (infants). Reduce dose or temporarily discontinue therapy. Hypothalamic-pituitary-thyroid axis will return to normal in 6-8 weeks. Serum T4 levels do not correlate well with toxicity. Provide general supportive care.
Acute: Acute overdose may cause fever, hypoglycemia, CHF, and unrecognized adrenal insufficiency. Acute massive overdose may be life-threatening; treatment should be symptomatic and supportive. Massive overdose may be a require beta-blockers for increased sympathomimetic activity.