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Lamisil 28 tabs
USD 99.00
USD 109.00
-
Lamisil 250mg
Novartis1 x 28 tabs » 250 mg/tab
General information:
Manufacturer: Novartis
Substance: Terbinafine
Pack: 28 tabs (250 mg/tab)
Lamisil
(terbinafine) is a medication used to treat infections caused by
certain types of fungus. It is most commonly used for skin and nail
infections. Generic terbinafine tablets are available.
Inhibits squalene epoxidase, resulting in ergosterol deficiency and a corresponding accumulation of squalene within the fungal cell leading to fungal cell death.
The course of treatment with Lamisil tablets is 12 weeks for toenail infections and 6 weeks for fingernail infections. The drug works faster than the nail grows. Therefore, it may be several months before new clear nails grow in. Lamisil is available in a once-a-day dosing with no dietary restrictions and can be taken with or without food.
USAGE:
Absorption from oral terbinafine is greater than 70%; bioavailability is about 40%. Lamisil (terbinafine) C max is 1 mcg/mL, T max occurs 2?h after a 250 mg dose. AUC is 4.56 mcg*h/mL and is increased less than 20% with food. At steady state in comparison to single dose, C max is 25% higher and AUC is increased 2.5 times.
Lamisil (terbinafine) is more than 99% protein bound and there are no specific binding sites. It is distributed to the sebum and skin.
Prior to excretion, Lamisil (terbinafine) is extensively metabolized by at least 7 CYP isoenzymes. There are no major metabolites that have antifungal activity similar to terbinafine.
Lamisil (terbinafine) half-life is 200 to 400 h, and the drug is about 70% eliminated in the urine.
SIDE EFFECTS:
Side effects that you should report to your prescriber or health care professional as soon as possible:
- dark yellow or brown urine
- fever or chills, cough, or sore throat
- loss of appetite
- nausea and vomiting
- redness, blistering, peeling or loosening of the skin, including inside the mouth
- skin rash, itching
- stomach or abdominal pain
- swelling, fluid retention
- unusual tiredness
- yellowing of skin or eyes
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
- headache
- changes in taste
- stomach upset
Inhibits squalene epoxidase, resulting in ergosterol deficiency and a corresponding accumulation of squalene within the fungal cell leading to fungal cell death.
The course of treatment with Lamisil tablets is 12 weeks for toenail infections and 6 weeks for fingernail infections. The drug works faster than the nail grows. Therefore, it may be several months before new clear nails grow in. Lamisil is available in a once-a-day dosing with no dietary restrictions and can be taken with or without food.
USAGE:
Absorption from oral terbinafine is greater than 70%; bioavailability is about 40%. Lamisil (terbinafine) C max is 1 mcg/mL, T max occurs 2?h after a 250 mg dose. AUC is 4.56 mcg*h/mL and is increased less than 20% with food. At steady state in comparison to single dose, C max is 25% higher and AUC is increased 2.5 times.
Lamisil (terbinafine) is more than 99% protein bound and there are no specific binding sites. It is distributed to the sebum and skin.
Prior to excretion, Lamisil (terbinafine) is extensively metabolized by at least 7 CYP isoenzymes. There are no major metabolites that have antifungal activity similar to terbinafine.
Lamisil (terbinafine) half-life is 200 to 400 h, and the drug is about 70% eliminated in the urine.
SIDE EFFECTS:
Side effects that you should report to your prescriber or health care professional as soon as possible:
- dark yellow or brown urine
- fever or chills, cough, or sore throat
- loss of appetite
- nausea and vomiting
- redness, blistering, peeling or loosening of the skin, including inside the mouth
- skin rash, itching
- stomach or abdominal pain
- swelling, fluid retention
- unusual tiredness
- yellowing of skin or eyes
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
- headache
- changes in taste
- stomach upset
